INDIVIDUAL SENSITIVITY TO GLUCOCORTICOIDS AND RESISTANCE TO HORMONES IN BRONCHIAL-ASTHMA

Authors
PALEEV NR ILCHENKO VA GOLIKOU PP STOTSKAYA TV KARANDASHOV VI KOLTSUN SS TISHENINA RS YURINA TM MASSARYGIN VV STADNIKOV LA
Citation
Nr. Paleev et al., INDIVIDUAL SENSITIVITY TO GLUCOCORTICOIDS AND RESISTANCE TO HORMONES IN BRONCHIAL-ASTHMA, Terapevticeskij arhiv, 66(12), 1994, pp. 56-59
Citations number
8
Categorie Soggetti
Medicine, General & Internal
Journal title
Terapevticeskij arhiv → ACNP
ISSN journal
00403660
Volume
66
Issue
12
Year of publication
1994
Pages
56 - 59
Database
ISI
SICI code
0040-3660(1994)66:12<56:ISTGAR>2.0.ZU;2-P
Abstract
The paper reports glucocorticoid actions in bronchial asthma, covers p roblems of individual sensitivity to glucocorticoids and resistance to hormones, illustrates the dependence of beclometasone dipropionate ef ficacy on condition of glucocorticoid receptors in alveolar macrophage s and clinical appearance of the disease,describes physiological featu res of patients with hormone-resistant bronchial asthma and its new tr eatment (extracorporeal photohemotherapy) allowing reduction of predni solone dose in 14 of 15 patients from 29.6 to 11.4 mg/day, on the aver age.