PRESENT-DAY ASPECTS OF DIARRHEA PATHOGENE SIS IN ULCERATIVE-COLITIS

The authors consider different mechanisms participating in progression of diarrhea in ulcerative colitis, The involvement of osmotic compone nt was suggested in view of incomplete hydrolysis of carbohydrates by small intestinal glucoamylase under mono- and bisubstrate digestion, w hereas diarrhea secretory component develops in participation of cycli c nucleotides. Motor mechanism is also present in diarrhea as evidence d by high concentrations of blood motilin and changes in intestinal ev acuation and motility. Polycomponent dysbioses detected in ulcerative colitis patients may also be essential for pathogenesis of diarrhea, D etermination of the leading component in each diarrhea case is thought helpful in valid choice of individual therapeutic policy.