THE GENOTOXICITY OF SUBSTITUTED NITROBENZENES AND THE QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES

Authors
HUANG QG WANG LS HAN SK
Citation
Qg. Huang et al., THE GENOTOXICITY OF SUBSTITUTED NITROBENZENES AND THE QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES, Chemosphere, 30(5), 1995, pp. 915-923
Citations number
10
Categorie Soggetti
Environmental Sciences
Journal title
Chemosphere → ACNP
ISSN journal
00456535
Volume
30
Issue
5
Year of publication
1995
Pages
915 - 923
Database
ISI
SICI code
0045-6535(1995)30:5<915:TGOSNA>2.0.ZU;2-L
Abstract
The genotoxicity of 22 substituted nitrobenzenes was evaluated by the chromosome aberrations test in cultured human peripheral lymphocytes. 18 of 22 compounds exhibit genotoxic activities. A quantitative struct ure-activity relationship model was established to correlate the genot oxicity of substituted nitrobenzenes and the characteristics of the su bstituents on the benzene ring.