THE INCOMPATIBILITIES BETWEEN CHLORHEXIDINE DIACETATE AND SOME TABLETEXCIPIENTS

The incompatibilities in a powder mixture for the manufacture of a che wable direct compression antiplague tablet preparate, were studied. Th e degree of loss of chlorhexidine diacetate in the presence of some co mmon tablet excipients was studied under high relative humidity (80 % RH) and in water solution. The most significant losses in water soluti on were observed with lubricants magnesium stearate and sodium lauryl sulphate. Under high relative humidity the greatest losses were, on th e contrary, observed with the materials having a great water absorptio n capacity, such as sodium carboxymethylcellulose and sodium starch gl ycolate.