RANDOMIZED, PROSPECTIVE, DOUBLE-BLIND-STUDY OF THE EFFECTS ON PAIN PERCEPTION OF LIDOCAINE JELLY VERSUS PLAIN LUBRICANT DURING OUTPATIENT RIGID CYSTOSCOPY

Purpose: There is no clear evidence that intraurethral lidocaine jelly decreases pain and/or makes rigid cystoscopy more tolerable for patie nts. Since lidocaine jelly is significantly more expensive than plain lubricant, we attempted to assess the true benefit of this agent. Mate rials and Methods: We performed a randomized, prospective, double-blin d study to compare the anesthetic effects of intraurethral 2% lidocain e jelly versus plain lubricant in patients undergoing rigid cystoscopy . Unlike previous studies, we ensured adequate urethral filling by usi ng 30 cc of each agent and we waited 20 minutes after instillation of the agent before performing cystoscopy to allow adequate absorption. C ystoscopy was performed using a 17 to 21F rigid instrument. A total of 189 patients was entered into the study but 10 were excluded from ana lysis due to incomplete questionnaires. A 10-point scale (1-least to 1 0-most painful) was used to measure pain perception. Results: In men p ain perception was significantly decreased when lidocaine jelly was us ed (mean plus or minus standard error 3.00 +/- 0.21 versus 4.36 +/- 0. 37 points, p = 0.002). In women there was no observed difference in pa in perception when lidocaine jelly or plain lubricant was used (3.21 /- 0.38 versus 3.11 +/- 0.30 points, p = 0.823). Patient race, perform ance of a related procedure, cystoscope size or history of cystoscopy did not significantly affect reported pain scores. There was a slight decrease in pain perception with increasing age (-0.23 +/- 0.10 points per decade, p = 0.021). The level of patient anxiety before cystoscop y was also significantly associated with pain perception (p < 0.001). Conclusions: Lidocaine jelly offers no advantage over plain lubricant in regard to pain control during rigid cystoscopy in women. However, w hen used in adequate amounts and allowed to dwell in the urethra for 2 0 minutes before cystoscopy, lidocaine jelly can significantly decreas e pain in men.