DOUBLE-LUMEN INFERIOR VENA-CAVA CATHETERS FOR PERIPHERAL STEM-CELL APHERESIS AND TRANSPLANTATIONS

No previously published studies have described double-lumen hemodialys is/apheresis catheters for use with continuous-flow apheresis collecti on of peripheral stem eel (PSC). We prospectively evaluated experience s with these catheters during both PSC collection and transplantation. Because of previously-described successful experiences with single-lu men apheresis catheters placed in the inferior vena cava, all catheter s evaluated in this study were placed in this anatomic location. Our e xperience demonstrated high rates of thrombotic occlusion (65%) and ca theter-related infections (l5%). This method of access should not be c onsidered optimal in its present state of use. Further investigation i nto preferred catheter design, anatomic location, and thrombosis proph ylaxis during continuous-flow apheresis is warranted.