THE TREATMENT OF NODE-NEGATIVE SQUAMOUS-CELL CARCINOMA OF THE POSTCRICOID REGION

This study includes 155 patients with T1-4N0 carcinoma of the postcric oid region seen between 1963 and 1993. Sixty-seven were treated by pri mary surgery, 50 by primary irradiation therapy, 36 were unsuitable fo r curative treatment and two patients were lost to follow-up. Reasons for deciding against curative therapy were: advanced age, poor general condition and advanced disease at the primary site. This study includ ed only those patients who had no neck node metastases at presentation . Patients receiving surgery tended to be in better general physical c ondition and tended to have more advanced disease than those treated b y irradiation in this series. The tumour-specific five-year survival r ate for those treated by surgery was 43 per cent (95 per cent confiden ce interval (CI) 23-60 per cent). For those patients treated by irradi ation the five-year survival rate was 48 per cent (95 per cent CI 27-6 6 per cent) and for those receiving no treatment the median survival r ate was three months (95 per cent CI two-six months). The observed sur vival for the surgery group was only 18 per cent and for the radiother apy group 25 per cent at five years. Multiple logistic regression show ed no significant difference in proportions of host and tumour factors between the group receiving radiotherapy and the group receiving surg ery. Recurrence at the primary site and the appearance of neck node me tastases were not predicted by any host or tumour factor. Twenty-one p atients out of 67 receiving primacy surgery had recurrence at the prim ary site compared with 26 patients out of 50 receiving primary irradia tion. Neck node metastases occurred in 16 out of 67 patients receiving surgery and in eight out of 50 receiving radiotherapy. The difference was statistically significant for recurrence at the primary site(chi( 1)(2) = 4.261; p = 0.039) but not significant for neck node metastases (chi(1)(2) = 0.661; p = 0.416). The data were further analysed using Cox's proportional hazards model for survival and no host or tumour fa ctors were found to be predictive of eventual outcome apart from poorl y differentiated histology. This adversely affected survival (chi(2) = 6.4444; p = 0.011). If patients not treated were included in the mode l, treatment became a significant factor in improving the survival (ch i 2 = 4.4197; p = 0.034). Radiotherapy appears to be at least as good as surgery for treating patients with an early carcinoma of the postcr icoid region. We would recommend radiotherapy is used in patients with no detectable neck node metastases and in tumours <5 cm long. The com plication rate from radiotherapy was reduced when compared with that o f surgery.