OBJECTIVE To evaluate the influence of peripheral neuropathy on body s
way assessed by posturography. RESEARCH DESIGN AND METHODS - The age-m
atched study subjects included 10 insulin-dependent diabetes mellitus
(IDDM) patients with peripheral neuropathy (DN), 23 IDDM patients with
out peripheral neuropathy (D) according to the San Antonio Consensus C
onference guidelines, and 21 control subjects (C). All subjects with s
ymptoms and/or clinical signs of postural instability were excluded fr
om the study. RESULTS - The trace surface was significantly larger in
the DN than in the C and D groups (P < 0.05), and the trace length was
longer in the DN than in the C and D groups (P < 0.01). Mean velocity
was faster in the DN than in the other two groups (P < 0.001). A dire
ct relationship was found between the parameters of posturography and
some parameters of the nerve conduction velocity. CONCLUSIONS - Diabet
ic patients with peripheral neuropathy demonstrate a relative deficit
in their ability to maintain posture. Posturography allows an early di
sclosure of the failure of postural control.