DEFECTIVE STEROL DELTA(5(6))DESATURASE AS A CAUSE OF AZOLE RESISTANCEIN USTILAGO-MAYDIS

Authors
JOSEPHHORNE T MANNING NJ HOLLOMON D KELLY SL
Citation
T. Josephhorne et al., DEFECTIVE STEROL DELTA(5(6))DESATURASE AS A CAUSE OF AZOLE RESISTANCEIN USTILAGO-MAYDIS, FEMS microbiology letters, 127(1-2), 1995, pp. 29-34
Citations number
20
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
127
Issue
1-2
Year of publication
1995
Pages
29 - 34
Database
ISI
SICI code
0378-1097(1995)127:1-2<29:DSDAAC>2.0.ZU;2-U
Abstract
Resistance to azole antifungals in Ustilago maydis was associated with a leaky defect in sterol Delta(5(6))desaturase. This defect resulted in reduced accumulation of 14 alpha-methylergosta-24(28)-diene-3 beta, 6 alpha-diol and an increase in the proportion of 14 alpha-methylfecos terol in treated cells when compared to the parent strain. The results demonstrate the importance of this mechanism in pathogenic fungi.