ABSORPTION OF INDOMETHACIN FROM NASAL CAVITY IN RATS

AIM: To investigate if identical bioavailability, rapid T-max, and C-m ax of indometacin (Ind) could be achieved when Ind is administered in rats via intranasal (ina) route. METHODS: The pharmacokinetics of Ind solution at a dosage of 3 mg . kg(-1) was studied after iv, ina, and p o in rats using HPLC. RESULTS: It showed that the time to peak (T-max) of ina Ind 3 mg . kg(-1) solution was 0.08 h, approached that after i v route the peak concentration (C-max) following ina was 20.0 mg . L(- 1), 2. 4 times higher than po dosing. CONCLUSION: It demonstrated that the ina administration of Ind was superior to po in rats, and that In d absorption through nasal mucosa was a reasonable approach at lower d oses.