Sx. Ying et Js. Cheng, NEUROPROTECTIVE EFFECTS OF DEXTROMETHORPHAN AGAINST TRANSIENT CEREBRAL-ISCHEMIA REPERFUSION INJURY IN GERBILS, Zhongguo yaoli xuebao, 16(2), 1995, pp. 133-136
AIM: To study the neuroprotective effects of dextromethorphan against
transient cerebral ischemia/reperfusion injury. METHODS: Transient cer
ebral ischemia/reperfusion injury in gerbils was produced by temporari
ly clamping the common carotid arteries (CCA) for 10 min. RESULTS: Int
rahippocampal (ih) injection of 2.0 mu L dextromethorphan (DM, 100 mu
mol . L(-1)) 5 min before ischemia quickened the recovery of EEG chang
es, the total power spectra of EEG, and the power of dominant frequenc
y following reperfusion. The total power of EEG was increased to 92 +/
- 30 (P < 0.01) at 240 min following reperfusion. DM substantially red
uced the severe ischemic neuronal damage (SIND) after 10 min of cerebr
al ischemia and 24 h of reperfusion. CONCLUSION: DM has neuroprotectiv
e effects against transient cerebral ischemia and reperfusion injury i
n gerbils.