PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) STIMULATESLH-RELEASE BY A DIRECT ACTION IN THE PITUITARY WITHOUT AFFECTING HYPOTHALAMIC GNRH RELEASE

Authors
LEONHARDT S ARIAS P FELEDER C MOGUILEVSKY J WUTTKE W JARRY H
Citation
S. Leonhardt et al., PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) STIMULATESLH-RELEASE BY A DIRECT ACTION IN THE PITUITARY WITHOUT AFFECTING HYPOTHALAMIC GNRH RELEASE, Neuro endocrinology letters, 17(1), 1995, pp. 13-19
Citations number
16
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
17
Issue
1
Year of publication
1995
Pages
13 - 19
Database
ISI
SICI code
0172-780X(1995)17:1<13:PAAP(S>2.0.ZU;2-I
Abstract
The effects of Pituitary adenylate cyclase activating polypeptide (PAC AP) on in vivo LH-and in vitro GnRH release were studied using hypotha lamus-lesioned rats and hypothalamic fragments, respectively. Since Gn RH secretion is not affected by PACAP but the peptide stimulates LH se cretion in hypothalamus-lesioned rats, we suggest that the physiologic al site of action of PACAP are the gonadotropes.