B. Gajkowska et M. Mossakowski, EFFECTS OF ISCHEMIA ON THE SEROTONIN NEURON SYSTEM IN RAT HIPPOCAMPUS- AN IMMUNOCYTOCHEMICAL STUDY, Neuro endocrinology letters, 17(1), 1995, pp. 57-62
Changes in serotonin (5-HT) immunoreactivity in axonal terminals in CA
1 region of the rat hippocampus were studied during cerebral ischemia,
with the immunogold procedure for electron microscopy. An increased 5
-HT-specific gold labelling immediately after ischemia was observed, S
ix, twelve, and twenty four hours after ischemia 5-HT immunoreactivity
was diminished. We thus provide an immunocytochemical evidence that c
erebral ischemia is accompanied by a rapid increase of 5-HT release in
the hippocampus, followed by 5-HT downregulation in the later post-is
chemic periods.