EFFECTS OF ISCHEMIA ON THE SEROTONIN NEURON SYSTEM IN RAT HIPPOCAMPUS- AN IMMUNOCYTOCHEMICAL STUDY

Authors
GAJKOWSKA B MOSSAKOWSKI M
Citation
B. Gajkowska et M. Mossakowski, EFFECTS OF ISCHEMIA ON THE SEROTONIN NEURON SYSTEM IN RAT HIPPOCAMPUS- AN IMMUNOCYTOCHEMICAL STUDY, Neuro endocrinology letters, 17(1), 1995, pp. 57-62
Citations number
17
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
17
Issue
1
Year of publication
1995
Pages
57 - 62
Database
ISI
SICI code
0172-780X(1995)17:1<57:EOIOTS>2.0.ZU;2-A
Abstract
Changes in serotonin (5-HT) immunoreactivity in axonal terminals in CA 1 region of the rat hippocampus were studied during cerebral ischemia, with the immunogold procedure for electron microscopy. An increased 5 -HT-specific gold labelling immediately after ischemia was observed, S ix, twelve, and twenty four hours after ischemia 5-HT immunoreactivity was diminished. We thus provide an immunocytochemical evidence that c erebral ischemia is accompanied by a rapid increase of 5-HT release in the hippocampus, followed by 5-HT downregulation in the later post-is chemic periods.