A NEW SUBCLASS OF ALKALOIDS FROM A DENDROBATID POISON FROG - A STRUCTURE FOR DEOXYPUMILIOTOXIN 251H

Authors
JAIN P GARRAFFO HM SPANDE TF YEH HJC DALY JW
Citation
P. Jain et al., A NEW SUBCLASS OF ALKALOIDS FROM A DENDROBATID POISON FROG - A STRUCTURE FOR DEOXYPUMILIOTOXIN 251H, Journal of natural products, 58(1), 1995, pp. 100-104
Citations number
11
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
58
Issue
1
Year of publication
1995
Pages
100 - 104
Database
ISI
SICI code
0163-3864(1995)58:1<100:ANSOAF>2.0.ZU;2-U
Abstract
Deoxypumiliotoxin 251H [4], representing a new subclass of the pumilio toxin-A class of alkaloids, has been isolated from a dendrobatid frog, Epipedobates tricolor. The structure, elucidated by nmr, gc-Ftir, and mass spectral analyses, is proposed to be an oxy-2-methylhexylidene)- 1-azabicyclo[4.3.0]nonane. The absolute stereochemistry and the relati ve configuration of the hydroxyl group are unknown.