The antiallergic activities of synthetic acrophylline [1] and acrophyl
lidine [2] have been demonstrated. Both compounds 1 and 2 at 30 mu mol
/kg reduced the plasma leakage in mouse ear in a passive cutaneous ana
phylactic (PCA) reaction. In addition, compound 1 suppressed mast cell
degranulation in a dose-dependent manner, while compound 2 at 100 mu
M produced no significant inhibition of the release of preformed infla
mmatory mediators. These results suggest that the antiallergic effect
of compound I probably occurs through the suppression of mast cell deg
ranulation, and that of compound 2 by protection of the vasculature ag
ainst challenge by mediators of inflammation.