ISOLATION OF ANTIFUNGAL AND LARVICIDAL CONSTITUENTS OF DIPLOLOPHIUM-BUCHANANI BY CENTRIFUGAL PARTITION CHROMATOGRAPHY

Three phenylpropanoids, myristicin [1], elemicin [2], and trans-isoele micin [3], together with two furanocoumarins, oxypeucedanin [4] and ox ypeucedanin hydrate [5], have been isolated from the leaves of Diplolo phium buchanani by a separation strategy involving the almost exclusiv e use of centrifugal partition chromatography. All five compounds were antifungal in a tie bioautography test using Cladosporium cucumerinum . Compounds 1-4 exhibited larvicidal activity against Aedes aegypti.