We report a patient with complete callosal disconnection syndrome afte
r severe closed head injury. MRI showed a complete destruction of the
corpus callosum throughout its length. Although traumatic callosal les
ions are a frequent finding in autopsy studies, as well as in some rec
ent MRI studies, clinical signs of callosal disconnection are rarely o
bserved after head injuries and a complete disconnection syndrome has
not been reported yet. This case study and the review of other reporte
d cases suggest that posttraumatic callosal disconnection is probably
often overlooked. Our patient had also a severe memory disorder that m
ight be partly related to the bilateral involvement of the fornix, as
this structure is closely adjacent to the posterior corpus callosum, a
nd was also shown by MRI to be very probably damaged.