F. Podczeck et al., THE DESCRIPTION OF THE GASTROINTESTINAL TRANSIT OF PELLETS ASSESSED BY GAMMA-SCINTIGRAPHY USING STATISTICAL MOMENTS, Pharmaceutical research, 12(3), 1995, pp. 376-379
The gastrointestinal transit of multiple units (e.g., pellets), as det
ermined by gamma scintigraphy, has been characterized by the applicati
on of statistical moments. Stomach emptying profiles can be described
comprehensively by Mean Gastric Residence Time (MGRT) and Variance of
Gastric Residence Time (VGRT) and caecum arrival data by Mean Caecum A
rrival Time (MCAT) and Variance of Caecal Arrival Time (VCAT). This ma
ximizes the data available, which is not the case when only described
as 50% values. The statistical moments provide different information a
bout the data observed compared to the classical descriptors, as there
was only limited correlation between these two sets of parameters. St
atistical moments therefore provide an important quantification of the
process studied, and they can be used in any statistical test, where
it is required to compare different experimental conditions.