Pregnancy may provide an opportunity for behavior change among women a
t high risk for HIV. Baseline and six-month follow-up data were collec
ted from a national sample of female injection drug users (IDUs) and s
exual partners of injection drug users (SPs), Repeated measures analys
es were conducted separately for three groups of IDUs (pregnant at bas
eline, became pregnant between baseline and follow-up, and not pregnan
t during the study) and three similar groups of SPs. Results indicated
that both pregnant and not pregnant high risk women reported signific
ant levels of risk reductions at follow-up. IDUs who were pregnant or
became pregnant reported greater reductions in drug injection rates, w
ere more likely to report entering drug treatment and reported the gre
atest reduction in sex compared to IDUs who were not pregnant. Results
suggest that the period of pregnancy provides an opportunity for chan
ges in risk behaviors, Innovative outreach efforts and increases in tr
eatment options are needed.