A human clone corresponding to the homologue of the murine Polycomb-li
ke gene M33 has been used to map this gene (CBX2) to human chromosomes
. Both somatic cell hybrid panels and FISH on metaphase chromosomes ha
ve been used. These techniques gave a consistent localization, at the
tip of the long arm of chromosome 17 (17q25). This localization, as we
ll as the potential role of a mammalian Polycomb-like protein, suggest
s a potential involvement in two different pathologies: the campomelic
syndrome, an inherited disorder, and neoplastic disorders linked to a
llele loss already described in this region. (C) 1995 Academic Press,
Inc.