ASSIGNMENT OF A POLYCOMB-LIKE CHROMOBOX GENE (CBX2) TO HUMAN-CHROMOSOME 17Q25

A human clone corresponding to the homologue of the murine Polycomb-li ke gene M33 has been used to map this gene (CBX2) to human chromosomes . Both somatic cell hybrid panels and FISH on metaphase chromosomes ha ve been used. These techniques gave a consistent localization, at the tip of the long arm of chromosome 17 (17q25). This localization, as we ll as the potential role of a mammalian Polycomb-like protein, suggest s a potential involvement in two different pathologies: the campomelic syndrome, an inherited disorder, and neoplastic disorders linked to a llele loss already described in this region. (C) 1995 Academic Press, Inc.