C. Shenberg et al., BR RB RATIO OBTAINED BY XRF ANALYSIS OF KIDNEYS OF NORMAL AND TUMOR-BEARING MICE TREATED WITH CIS-DDP/, Journal of trace elements and electrolytes in health and disease, 8(3-4), 1994, pp. 177-182
The Br/Rb ratio in kidneys of normal and tumor-bearing mice was studie
d and a significant difference was found between the two groups. The m
ice were treated with cis-DDP with and without selenite, with selenite
alone, and compared with controls. The animals were sacrificed 7d, 14
d, and 21-28d after treatment. The kidneys were removed and subjected
to Br and Rb determination by a novel X-ray fluorescence (XRF) method.
The results are presented in terms of estimated net count rates under
the BrK alpha and RbK alpha peaks. No significant differences were fo
und in Br and Rb levels or in the Br/Rb ratio in kidneys of treated an
d untreated mice belonging to the same group - normals or lung carcino
ma inoculated. However, there was a significant difference in the Br/R
b ratio between the two tested groups (normal and inoculated). Prelimi
nary results on the Br/Rb ratio obtained from normal and malignant tis
sues of colorectal cancer (CRC) patients and from mice inoculated with
melanoma show the same trend as those from the group of mice with lun
g carcinoma. In all three groups tested the Br/Rb ratio was 2-4 times
higher in normal than in malignant tissue.