SOLVENT EFFECT ON ENANTIOSELECTIVE HYDROGENATION OF (E)-ALPHA-PHENYLCINNAMIC ACID WITH CINCHONIDINE-MODIFIED PALLADIUM CATALYSTS

Authors
NITTA Y KOBIRO K
Citation
Y. Nitta et K. Kobiro, SOLVENT EFFECT ON ENANTIOSELECTIVE HYDROGENATION OF (E)-ALPHA-PHENYLCINNAMIC ACID WITH CINCHONIDINE-MODIFIED PALLADIUM CATALYSTS, Chemistry Letters, (2), 1995, pp. 165-165
Citations number
6
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
2
Year of publication
1995
Pages
165 - 165
Database
ISI
SICI code
0366-7022(1995):2<165:SEOEHO>2.0.ZU;2-X
Abstract
The use of a solvent with larger dielectric constant results in higher enantioselectivity in the hydrogenation of (E)-alpha-phenylcinnamic a cid with a cinchonidine-modified Pd catalyst. The reaction in N,N-dime thylformamide containing 10vol% of water with a 5wt% Pd/TiO2 catalyst leads to an optical yield of 53% of S-(+)-2,3-diphenylpropionic acid.