Purpose: The use of autogenous vein, whether in situ or excised, for a
rterial bypass procedures is well accepted. However, this usually requ
ires the presence of a length of good-quality vein of adequate diamete
r. In patients lacking sufficient length of vein, two or more pieces o
f vein may be spliced together to complete the reconstruction. The eff
ect of vein splicing on vein bypass patency is not well studied. Metho
ds: Over a 14-year period, 1956 lower extremity revascularizations wer
e performed with a single autogenous vein, 1806 in situ and 150 excise
d veins. During the same time, 184 bypasses required splicing vein seg
ments together, of which 111 were in situ bypass: procedures, which re
quired splicing of one or more pieces of excised vein to complete the
reconstruction (partial in situ bypass). Seventy-three bypasses were c
ompleted with multiple pieces of spliced excised vein. The source for
the excised, spliced vein segments was the distal ipsilateral greater
saphenous vein (GSV) in 40%, accessory ipsilateral GSV in 8%, contrala
teral GSV in 13%, lesser saphenous vein in 28%, and arm vein in 11%. R
esults: The 1- and 4-year primary patency rates for the entire spliced
vein group were 72% and 45%, with secondary patency rates of 79% and
61%. The 1- and 4-year secondary patency rates of partial in situ bypa
sses were 80% and 70%, compared with 91% and 83% for in situ bypasses
completed without a spliced segment (p < 0.0001). The 1- and 4-year se
condary patency rates were 78% and 67% in the spliced excised vein gro
up and 85% and 75% in the single excised vein group (p = not significa
nt). The 4-year limb salvage rates were as follows: in situ (96%), par
tial in situ (85%), single excised vein (95%), and spliced excised vei
n (90%). Conclusions: We conclude that the use of excised vein segment
s to complete partial in situ bypasses may be associated with a decrem
ent of bypass patency. Use of spliced excised vein segments of good qu
ality for arterial bypass can produce acceptable patency rates. Such s
pliced autogenous conduits are clearly preferable to prosthetic bypass
es for infrageniculate arterial reconstructions. Meticulous technique
is a prerequisite for the successful performance of vein-to-vein anast
omoses.