Eh. Chudler et al., MULTISENSORY CONVERGENCE AND INTEGRATION IN THE NEOSTRIATUM AND GLOBUS-PALLIDUS OF THE RAT, Brain research, 674(1), 1995, pp. 33-45
The extracellular response properties of neurons in the caudate-putame
n (CPu), globus pallidus (GP) and lateral amygdaloid nucleus (La) evok
ed by auditory and somatosensory stimuli were investigated. A total of
61 neurons in these areas responded either singly to somatosensory st
imulation (unisensory), or to both somatosensory and auditory stimulat
ion (multisensory). Higher rates of somatosensory stimulation reduced
the response magnitude of CPu neurons more than that of GP neurons. In
multisensory neurons, combined somatosensory and auditory stimulation
compared to unisensory stimulation resulted in three characteristic r
esponse patterns: enhancement, depression or interaction. Temporal mis
alignment of the peak frequency latencies evoked by auditory and somat
osensory stimulation altered the response magnitude in the majority of
neurons. The response properties and anatomical connectivity of CPu a
nd GP neurons suggest that the observed multisensory integrative effec
ts may be used to facilitate motor responses to low intensity stimuli.