EFFECTS OF IN-VITRO ETHANOL AND CHRONIC ETHANOL-CONSUMPTION ON THE RELEASE OF EXCITATORY AMINO-ACIDS IN THE RAT HIPPOCAMPUS

Authors
SEPULVEDA C BUSTOS G GYSLING K SEGUEL M LABARCA R
Citation
C. Sepulveda et al., EFFECTS OF IN-VITRO ETHANOL AND CHRONIC ETHANOL-CONSUMPTION ON THE RELEASE OF EXCITATORY AMINO-ACIDS IN THE RAT HIPPOCAMPUS, Brain research, 674(1), 1995, pp. 104-106
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
674
Issue
1
Year of publication
1995
Pages
104 - 106
Database
ISI
SICI code
0006-8993(1995)674:1<104:EOIEAC>2.0.ZU;2-V
Abstract
In CA1-CA3 hippocampal slices, in vitro ethanol (EtOH) (10-100 mM) evo ked, as a function of EtOH concentration, a differential release of as partate (Asp) and glutamate (Glu). Omission of Ca2+ ions from the supe rfusion media completely abolished the EtOH-induced release of Asp but not that of Glu. In addition, at 20 mM, EtOH enhanced K+-evoked relea se only of Asp. Finally, delayed changes were observed on NMDA-evoked release of [H-3]noradrenaline (NA) in the dentate gyrus (DG) after wit hdrawal from EtOH for 30 days.