EXPERIMENTS DIRECTED TOWARDS THE SYNTHESIS OF ANTHRACYCLINONES .26. THE PREPARATION OF CHIRAL INTERMEDIATES FOR ANTHRACYCLINONE SYNTHESIS

Authors
BEAUREGARD DA CAMBIE RC DANSTED PC RUTLEDGE PS WOODGATE PD
Citation
Da. Beauregard et al., EXPERIMENTS DIRECTED TOWARDS THE SYNTHESIS OF ANTHRACYCLINONES .26. THE PREPARATION OF CHIRAL INTERMEDIATES FOR ANTHRACYCLINONE SYNTHESIS, Australian Journal of Chemistry, 48(3), 1995, pp. 669-676
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Australian Journal of Chemistry → ACNP
ISSN journal
00049425
Volume
48
Issue
3
Year of publication
1995
Pages
669 - 676
Database
ISI
SICI code
0004-9425(1995)48:3<669:EDTTSO>2.0.ZU;2-4
Abstract
(2'R)-1,5-Dimethoxy-2(2'-methyloxiran-2'-y (8), an intermediate for th e synthesis of fridamycin E, has been prepared enantioselectively via the diol (15). The diol (15) was prepared in high yield by asymmetric cis-hydroxylation of the alkene (11). The analogous diol (22), a vineo mycinone B-2 precursor, was also prepared.