Y. Ozkul et al., SISTER-CHROMATID EXCHANGE INDUCING EFFECT OF SMOKELESS TOBACCO USING ON T-LYMPHOCYTE CHROMOSOMES, Mutation research. Section on environmental mutagenesis and related subjects, 334(2), 1995, pp. 209-212
A kind of a smokeless tobacco (Maras powder) is widely used instead of
cigarettes in the South Eastern region of Turkey. In this study we in
vestigated the sister-chromatid exchange (SCE) inducing effect of this
powder on the chromosomes of its users compared with smokers and nons
mokers using standard cell culture methods and SCE staining techniques
. Average SCE per metaphase and total SCEs increased significantly amo
ng both smokeless tobacco users and smokers compared to nonsmokers (p
< 0.01). However, the effect is significantly lower in smokeless tobac
co users than in smokers (p < 0.05).