A. Ronkainen et al., INTRACRANIAL ANEURYSMS - MR ANGIOGRAPHIC SCREENING IN 400 ASYMPTOMATIC INDIVIDUALS WITH INCREASED FAMILIAL RISK, Radiology, 195(1), 1995, pp. 35-40
PURPOSE: To evaluate the accuracy and limitations of magnetic resonanc
e (MR) angiographic screening for incidental intracranial aneurysms (I
As) in healthy individuals with a family history of IA. MATERIALS AND
METHODS: Four hundred asymptomatic individuals in 68 families with a h
istory of aneurysmal subarachnoid hemorrhage underwent MR angiography.
Six families also had a history of polycystic kidney disease. A multi
slab, three-dimensional, time-of-flight sequence was used. Conventiona
l angiography was performed to confirm positive MR angiographic findin
gs. RESULTS: IAs were detected with MR angiography in 37 individuals,
32 of whom underwent conventional angiography. Intraobserver consisten
cy was excellent (kappa = 0.96), and interobserver reproducibility was
good to excellent (kappa = 0.59-0.82). Both techniques showed similar
results in the evaluation of size, localization, and orientation of a
neurysms and visibility of the aneurysm neck. CONCLUSION: MR angiograp
hy is an accurate and feasible method of noninvasive screening for IAs
in individuals at high risk. Conventional angiography is still necess
ary before operative treatment.