IS TIME-INTERVAL BETWEEN MINI-PILL INGESTION AND BREAST-FEEDING ESSENTIAL

A study was conducted on four alternate days over an eight-day period in a group of 12 healthy, 20-35 year old exclusively breast feeding wo men two were interested in weaning their infants. On each study day th e women ingested 150 mu g levonolgestrel. Maternal blood and milk samp les were collected at 2, 4, 6, and 8 hr intervals after LNG ingestion on the 1st, 3rd, 5th, and 8th day. A time-dependent decrease in matern al serum and increase in breast milk levels of LNG were observed. Main taining a time interval between mini-pill intake and breast-feeding re sults in higher levels of LNG in breast milk, thereby exposing the inf ant to a bolus of LNG in a ''single-delayed'' feed.