UNDIFFERENTIATED EMBRYONAL SARCOMA OF THE LIVER TREATED WITH CHEMOTHERAPY - CT IMAGING IN 4 PATIENTS

Background: The purpose of this study was to describe the computed tom ography (CT) findings of undifferentiated embryonal sarcoma after chem otherapy and to correlate the CT imaging findings with pathologic find ings. Methods: Ten CT images obtained before and after chemotherapy in four patients with hepatic undifferentiated embryonal sarcoma were re trospectively reviewed and correlated with pathologic findings. Result s: After chemotherapy, tumor volume decreased by 50-90% and initially nonresectable tumor or gross residual tumor was successfully excised i n three patients. In all patients, enhancing peripheral solid portions and septations changed to low-attenuation areas, and in three patient s increased or de novo calcifications were found at the periphery of t he tumor. Resected pathologic specimen after chemotherapy showed well- encapsulated masses with central necrosis, fibrosis, and dystrophic ca lcifications. Conclusions: These CT findings will be useful in mon ito ring the treatment response of hepatic undifferentiated embryonal sarc oma during chemotherapy.