BACKGROUND Ovarian cancer can be cured if detected early enough, but u
sually has already metastasized when diagnosed. A family history of ov
arian cancer is still the strongest known risk factor. OBJECTIVE To id
entify women at risk for ovarian cancer and design a program of survei
llance. METHODS Prospective registry of women with a family history of
ovarian cancer.RESULT From April 1991 to July 1993, 137 women (119 fa
milies), mean age 43, registered with the Familial Ovarian Cancer Regi
stry. The 119 pedigrees revealed 171 cases of ovarian cancer. Only one
family is undocumented by pathology. Forty of 131 registrants have mo
re than one relative with ovarian cancer. Six percent of pelvic examin
ations were abnormal for potential adnexal disease. In 4% of registran
ts, initial CA125 concentrations were abnormal. Ultrasound examination
s were abnormal in ovarian size (5%), in morphology (3%), and by resis
tive indices (4%). Four ultrasounds were repeated earlier than routine
. Using ''standard'' fees, the total cost to diagnose the one case of
ovarian cancer discovered was $68 848. CONCLUSIONS This approach still
cannot be considered cost-effective. We are continuing to search for
genetic and molecular markers of disease in women at greatest risk and
in their affected relatives.