ANTIINFLAMMATORY MECHANISM OF CORDIACHROMENE-A ACTION

Authors
BENSLIMANE AF POUCHUS YF VERBIST JF PETIT JY BRION JD WELIN L
Citation
Af. Benslimane et al., ANTIINFLAMMATORY MECHANISM OF CORDIACHROMENE-A ACTION, Journal of clinical pharmacology, 35(3), 1995, pp. 298-301
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of clinical pharmacology → ACNP
ISSN journal
00912700
Volume
35
Issue
3
Year of publication
1995
Pages
298 - 301
Database
ISI
SICI code
0091-2700(1995)35:3<298:AMOCA>2.0.ZU;2-U
Abstract
The mechanism of antiinflammatory action of cordiachromene A, isolated from the chloromethylenic extract of the ascidian Aplidium antillense or chemically synthesized, was studied using different in vivo and in vitro inhibition tests on enzymes of the cyclooxygenase cascade. Cord iachromene A inhibits prostacyclin synthesis and arachidonic acid meta bolism but not phospholipase A(2) and peroxidase. The mechanism of act ion, already known to be stereospecific, operates by cyclooxygenase in hibition.