AQUEOUS SOLUBILITIES OF ALKYLPHENOLS AND METHOXYPHENOLS AT 25-DEGREES-C

The aqueous solubilities of 25 phenolic substances (2-methylphenol; 3- methylphenol; 4-methylphenol; 2,3-dimethylphenol; 2,4-dimethylphenol; 2,5-dimethylphenol; 2,6-dimethylphenol; 3,4-dimethylphenol; 3,5-dimeth ylphenol; 2-ethylphenol; 4-ethylphenol; 2,3,5-trimethylphenol; 2,4,6-t rimethylphenol; 3,4,5-trimethylphenol; 4-propylphenol; 2-isopropylphen ol; 4-isopropylphenol; 4-butylphenol; 3-tert-butylphenol; 4-tert-butyl phenol; 4-hexylphenol; 3,5-di-tert-butylphenol; 4-octylphenol; 3-metho xyphenol; and 4-methoxyphenol) were determined at 25 degrees C, by a c onventional shake-flask, batch contacting method with analysis by high -pressure Liquid chromatography with UV detection. Satisfactory agreem ent was obtained between measured and previously reported solubilities for 10 of these substances. The liquid or supercooled liquid solubili ties are satisfactorily correlated with the solute's LeBas molar volum e and with first-order valence molecular connectivity, yielding struct ure-property relationships that may be useful for predictive purposes.