THE HEPARIN-LIKE ANTIPROLIFERATIVE ACTIVITY OF SULFATED TETRASACCHARIDES IS SENSITIVE TO STRUCTURAL VARIATION

Authors
WESSEL HP VIEIRA E TRUMTEL M TSCHOPP TB IBERG N
Citation
Hp. Wessel et al., THE HEPARIN-LIKE ANTIPROLIFERATIVE ACTIVITY OF SULFATED TETRASACCHARIDES IS SENSITIVE TO STRUCTURAL VARIATION, Bioorganic & medicinal chemistry letters, 5(5), 1995, pp. 437-442
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
5
Year of publication
1995
Pages
437 - 442
Database
ISI
SICI code
0960-894X(1995)5:5<437:THAAOS>2.0.ZU;2-7
Abstract
The sulfated tetrasaccharide beta-maltosyl-(1-->4)-alpha,alpha-trehalo se 2 with high antiproliferative activity on smooth muscle cells was m odified in the maltosyl moiety by linking eight different disaccharide s equatorially to trehalose; the biological activity varied strongly b etween different structures.