SYNTHESIS OF MYO-INOSITOL-1-PHOSPHATASE INHIBITORS IN WHICH THE PHOSPHATE GROUP IS REPLACED BY LESS POLAR GROUPS

Authors
VANSTEIJN AMP WILLEMS HAM DEBOER T GEURTS JLT VANBOECKEL CAA
Citation
Amp. Vansteijn et al., SYNTHESIS OF MYO-INOSITOL-1-PHOSPHATASE INHIBITORS IN WHICH THE PHOSPHATE GROUP IS REPLACED BY LESS POLAR GROUPS, Bioorganic & medicinal chemistry letters, 5(5), 1995, pp. 469-474
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
5
Year of publication
1995
Pages
469 - 474
Database
ISI
SICI code
0960-894X(1995)5:5<469:SOMIIW>2.0.ZU;2-8
Abstract
The phosphate group in the inositol-1-phosphatase inhibitor (1) is rep laced by less polar phosphorus containing groups (substituted phosphat e and phosphonates), by sulphur containing substituents (sulphate, sul phonamides) and by a carboxylate and carbamate. The effect of the repl acement is studied on the enzyme myo-inositol-1-phosphatase.