NONPEPTIDE GLYCOPROTEIN IIB IIIA INHIBITORS .6. DESIGN AND SYNTHESIS OF RIGID, CENTRALLY CONSTRAINED NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS/

Low molecular weight non-peptide inhibitors of platelet aggregation ba sed on rigid bycyclic scaffolds are described. Consideration of the re ported conformational preferences of 1-alkyl-3-carbonyl pyrroles led t o the synthesis of pyrrolopiperazinone 2a which was shown to be a pote nt, selective antagonist.