PROTEIN-KINASE C-ALPHA INHIBITORS - STRUCTURE-ACTIVITY-RELATIONSHIPS IN BIS-INDOLE SERIES

Authors
XIE GJ ZIMMERMANN J MEYER T LOWN JW
Citation
Gj. Xie et al., PROTEIN-KINASE C-ALPHA INHIBITORS - STRUCTURE-ACTIVITY-RELATIONSHIPS IN BIS-INDOLE SERIES, Bioorganic & medicinal chemistry letters, 5(5), 1995, pp. 497-500
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
5
Year of publication
1995
Pages
497 - 500
Database
ISI
SICI code
0960-894X(1995)5:5<497:PCI-SI>2.0.ZU;2-M
Abstract
To assess the role of the amine and ester containing oligopeptide side -chains in bis-indole protein kinase C inhibitors, six novel hybrids i n this series were synthesized. These new compounds displayed effectiv e inhibitory activity against protein kinase C-alpha.