THE DESIGN, SYNTHESIS AND EVALUATION OF A,C,D-RING ANALOGS OF THE FUNGAL METABOLITE K-76 AS COMPLEMENT INHIBITORS - A POTENTIAL PROBE FOR THE ABSOLUTE STEREOCHEMISTRY AT POSITION-2

In an attempt to synthesize stereochemically pure new A, C, D-ring ana logs of the natural product complement inhibitor K-76, compounds (20-2 4) were prepared and the representative one (23) was evaluated for its ability to inhibit complement-mediated erythrocyte lysis in both the classical and alternative pathways. Compounds synthesized as part of t his study suggest that the terpenoid diol component of K-76 may not he essential for complement inhibition.