CORRELATION OF PHARMACOLOGICAL PROPERTIES OF A GROUP OF BETA-BLOCKER AGENTS BY MOLECULAR TOPOLOGY

The molecular connectivity method has been applied to the study of pha rmacological properties, among which are found the angor treatment dos e, alpha-distribution half-life and intravenous LD50 in mouse, of a gr oup of beta-blocker agents, verifying its application in the predictio n of theoretic values for said pharmacological properties. To do this, the obtained multiple regression functions of the corresponding conne ctivity indices were used in relation with the experimental values of the properties, which are accompanied by the statistical parameters us ed in their selection criteria, as well as the corresponding random an d cross-validation studies of said functions, which corroborate the go od correlation of the selected equations.