The incidence of seizures reported with imipenem use varies. Risk fact
ors such as excessive dosage, renal insufficiency, underlying central
nervous system disorders, and prior history of seizures have been corr
elated to seizure occurrence. The objectives of this study weve to det
ermine the incidence of seizures associated with the use of imipenem a
t our institution and to compare the presence of risk factors in patie
nts who developed seizures with those who did not.