R. Cavalli et al., PREPARATION AND EVALUATION IN-VITRO OF COLLOIDAL LIPOSPHERES CONTAINING PILOCARPINE AS ION-PAIR, International journal of pharmaceutics, 117(2), 1995, pp. 243-246
Aqueous dispersions of solid lipospheres containing up to 7.5% pilocar
pine as lipophilic ion pairs were submitted to a preliminary evaluatio
n. The lipospheres (diameter 75-85 nm) consisted mainly of stearic aci
d and egg lecithin; pilocarpine base was incorporated as ion pair with
mono-octylphosphate, monodecylphosphate and monohexadecylphosphate. T
he following parameters were investigated: stability constants (beta)
and lipophilicity of the ion pairs, size, porydispersity and drug cont
ent of the lipospheres, pilocarpine release in vitro. The preparations
might constitute a promising vehicle for sustained ocular delivery of
pilocarpine.