A 3-YEAR STABILITY STUDY OF TOLBUTAMIDE SOLID DISPERSIONS AND BETA-CYCLODEXTRIN COMPLEX

Authors
KEDZIEREWICZ F VILLIERAS F ZINUTTI C HOFFMAN M MAINCENT P
Citation
F. Kedzierewicz et al., A 3-YEAR STABILITY STUDY OF TOLBUTAMIDE SOLID DISPERSIONS AND BETA-CYCLODEXTRIN COMPLEX, International journal of pharmaceutics, 117(2), 1995, pp. 247-251
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
117
Issue
2
Year of publication
1995
Pages
247 - 251
Database
ISI
SICI code
0378-5173(1995)117:2<247:A3SSOT>2.0.ZU;2-O
Abstract
The aim of this work was to compare the effect of aging on tolbutamide solid dispersions with PEG 6000 and tolbutamide-beta-cyclodextrin inc lusion complex stored at three temperatures for 3 years. The effect of aging was displayed by comparing the physicochemical characteristics followed by X-ray diffractometry, infrared spectrophotometry and diffe rential thermal analysis as well as the dissolution profiles of these compounds. The results obtained showed that tolbutamide-PEG 6000 solid dispersions and tolbutamide-beta-cyclodextrin inclusion complex were stable for the 3 years of the study.