MOLECULAR CHAPERONES IN ANTIGEN PRESENTATION

As is the case with most proteins of the secretory pathway, the biogen esis of MHC class I and class II molecules occurs in association with molecular chaperones. Considerable progress has been made in identifyi ng the chaperones involved acid recent studies on two of these, calnex in and invariant chain, have shown that they influence multiple proces ses including protein stability, folding, assembly and intercellular r etention.