Jl. Rutgers et al., ANGIOGENESIS IN UTERINE CERVICAL SQUAMOUS-CELL CARCINOMA, International journal of gynecological pathology, 14(2), 1995, pp. 114-118
This study tested the hypothesis that increased angiogenesis in squamo
us cell carcinoma of the cervix is an indicator of poor prognosis, We
retrospectively studied 70 cases and related the microvessel count to
stage and follow-up. We performed immunohistochemical staining for Fac
tor VIII and counted the number of microvessels in a 400x field in the
area of greatest density of vessels. The mean vessel count in stage I
was 18.3 +/- 5.4 (26 cases), in stage II 18.0 +/- 6.8 (21 cases), in
stage III 17.9 +/- 3.9 (18 cases), and in stage IV 22.2 +/- 13.6 (five
cases). We found no correlation between the mean vessel count and sta
ge (p < 0.85) or between mean vessel count and disease status on an av
erage follow-up of 21 months (p < 0.65), With a power of similar to 70
%, this study excludes the hypothesis that an increased density of mic
rovessels is associated with a worsened prognosis in cervical squamous
cell carcinoma,