ARTERIAL THROMBOSIS ASSOCIATED WITH GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) ADMINISTRATION IN BREAST-CANCER PATIENTS TREATED WITH DOSE-INTENSIVE CHEMOTHERAPY - A REPORT OF 2 CASES

The occurrence of arterial thrombosis reported in other breast cancer series has largely been confined to the upper extremities, ipsilateral to a previous mastectomy site and clinically manifest as cerebral vas cular accidents. This case report describes 2 patients who experienced iliac artery thrombosis temporally related to receiving granulocyte-m acrophage colony-stimulating factor (GM-CSF) and dose-intensive chemot herapy for metastatic breast cancer. A review of the literature concer ning arterial thrombosis as relevant to breast cancer treatment and GM -CSF is included.