METHOTREXATE TREATMENT OF CERVICAL PREGNANCIES WITH DIFFERENT CLINICAL-PARAMETERS - A REPORT OF 3 CASES

Three cases of cervical pregnancy with different clinical parameters w ere successfully treated with methotrexate. Case 1 was a viable cervic al pregnancy, case 2 was a cervical pregnancy after curettage that dev eloped into a cervical hematoma, and case 3 was a cervical pregnancy a t an early gestational age. The interval between diagnosis and treatme nt ranged from 45 to 76 days. The maximum quantitative beta-human chor ionic gonadotropin (beta-hCG) levels in cases 1, 2 and 3 were 100, 180 , 19,093 and 956 mIU/mL, respectively. These patients showed a progres sive decline in beta-hCG levels, and ultrasound showed a gradual decre ase in the size of the pregnancies. The interval between treatment and beta-hCG resolution ranged from 14 to 59 days. Only in case 2 did sid e effects occur, including stomatitis and transient elevation of serum transaminase. In view of the risks of standard therapy and patients' desire for fertility, methotrexate treatment may be a therapeutic alte rnative for cervical pregnancy.