During a protocol study for the efficacy of fluparoxan (a noradrenegic
alpha(2)-antagonist) in depression, a positive effect on male erectil
e impotence has been observed in one case, with no important secondary
effects. This result confirms the involvement of alpha(2)-antagonsts
in the handling of male impotence. The action on the erectile disorder
appeared slightly before the antidepressive effect (2-3 weeks) and la
sted for 6 weeks after the discontinuation of treatment, suggesting th
at the effects on impotence were not a mere reflection of the antidepr
essive action.