Nb. Atkin et al., CHROMOSOME-ABNORMALITIES AND P53 EXPRESSION IN A SMALL-CELL CARCINOMAOF THE BLADDER, Cancer genetics and cytogenetics, 79(2), 1995, pp. 111-114
Chromosome studies on a highly malignant tumor, a small cell carcinoma
of the bladder (the first to be studied cytogenetically), showed a hy
pertriploid mainline and a hypertetraploid minor line. Extensive chrom
osomal rearrangements were present in both lines, some rearranged chro
mosomes being seen in only one of the lines, while others, derived fro
m chromosomes 6, 9, 11, 13, and 18, were seen in both. Although differ
ent giant chromosomes were present in the two lines, they shared a pos
sibly significant common feature: multiple copies of 2q. DNA flow cyto
metry confirmed that the tumor had a hypertriploid main mode and showe
d that dysplastic surface epithelium present in the histologic materia
l also had a hypertriploid DNA index. p53 expression in the tumor was
demonstrated by flow cytometry.