MONOSOMY 1P IS CORRELATED WITH ENHANCED IN-VIVO GLUCOSE-METABOLISM INMENINGIOMAS

Authors
HENN W CREMERIUS U HEIDE G LIPPITZ B SCHRODER JM GILSBACH JM BULL U ZANG KD
Citation
W. Henn et al., MONOSOMY 1P IS CORRELATED WITH ENHANCED IN-VIVO GLUCOSE-METABOLISM INMENINGIOMAS, Cancer genetics and cytogenetics, 79(2), 1995, pp. 144-148
Citations number
20
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
79
Issue
2
Year of publication
1995
Pages
144 - 148
Database
ISI
SICI code
0165-4608(1995)79:2<144:M1ICWE>2.0.ZU;2-K
Abstract
The 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake of 25 human meningiom as was preoperatively evaluated in vivo by positron-emission tomograph y (PET). After surgery, meningioma biopsies were analyzed cytogenetica lly. Five meningiomas showed partial monosomy for chromosome 1p additi onal to other typical chromosome aberrations. This aberrant karyotype was correlated with increased FDG uptake. Three of five meningiomas wi th monosomy 1p were classified as grade II according to WHO, while onl y one of 20 tumors without monosomy 1p was classified as grade II. Thu s, monosomy 1p and elevated FDG uptake in PET ore to be regarded as cy togenetic and metabolic parameters for the aggressiveness of meningiom as.