R. Bonomi et al., IS TRISOMY-4 A SECONDARY CHROMOSOMAL ABNORMALITY IN ACUTE MYELOBLASTIC-LEUKEMIA, Cancer genetics and cytogenetics, 79(2), 1995, pp. 186-187
Cytogenetic studies were carried out in a patient with acute monocytic
leukemia (AML-M5) at diagnosis and in relapse. While no chromosome ab
normality was detected initially, isolated trisomy 4 was found in rela
pse. The primary or secondary nature of trisomy 4 as the sole abnormal
ity in AML is discussed.